The most likely answer to the crossword clue First couple of children in A&E hurt is ACHE.
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Likely related crossword clues
|First couple of children always bringing happiness
|Children’s game with children a bit of a pain
|Children, children, somewhat wet
|1881 NOVEL “FOR CHILDREN AND THOSE WHO LOVE CHILDREN” (5)
|1881 NOVEL “FOR CHILDREN AND THOSE WHO LOVE CHILDREN”
|Suppressing that hurt, couple make up, if they’re lucky
|Hurt a couple of girls, ever one is troubled